EFFECT OF PROCAINAMIDE ON ULTRASTRUCTURE OF BLOOD PLATELET IN RABBITS
1998
AIM: To study the effect of procainamide (PA) on the ultrastructure of blood platelets. METHODS: Arachidonic acid was added to PA-treated platelet-rich plasma to induce platelet aggregation. The 50-nm sections were examined with a transmission electron microscope.
RESULTS: PA 8.5-136 mumol.L-1 markedly inhibited changes of pseudopods, alpha-granules, dense granules, glycogens, open canalicular system, and dense tubular system.
CONCLUSION: PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.
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