Recent advances in the development of metal-organic framework-based gas nanoplatforms for synergistic cancer therapy

Featuring high therapeutic efficacy, biocompatibility, and biosafety, gas therapy as a burgeoning and promising research field has attracted considerable attention in biomedicine. However, the lack of the tumor site accumulation and controlled release of therapeutic gas molecules limited the therapeutic efficacy. Therefore, development of gas-releasing nanoplatforms to realize tumor-targeting and controllable release is greatly desired.The structural diversity and tailorability as well as ultrahigh surface area make metal-organic frameworks (MOFs) find their potential applications in gas or gas releasing molecules (GRMs) delivery and release. In this Frontier article, we provide an overview of recent developments achieved in gas-involving cancer therapy over MOFs and MOF-based materials. The main emphasis is focused on design of multifunctional MOF-based nanoplatforms for therapeutic gas molecules delivery and release, and emphasizing their synergistic mechanism against tumor. Moreover, the challenges, future trends, and prospects of gas-related cancer therapy are also discussed