Effect of single-dose dexmedetomidine on general anesthesia in laparoscopic cholecystectomy

Objective To observe the effect of single dose dexmedetomine (Dex) on general anesthesia in laparoscpic cholecystectomy.Methods Fifty ASA Ⅰ -Ⅱ patients of both sexes,aged 21 y-57 y,weighing 42.5 kg-80 kg undergoing elective laparoscopic cholecystectomy (LC),were randomly divided into 2 groups (n=25):dexmedetomidine (Dex) group (group D) and control group (group C).Group C received normal saline 10 ml given within 10 min.Group D received equal volume of Dex 0.6 μg/ kg intravenously as group C.MAP and HR were recorded at the time points of pre-administration of Dex (T0),5 min after administration(T1),before anesthesia induction(T2),1 min and 2 min after injecting propofol respectively(T3-4),immediately after intubation (T5),1,3 min and 5 min after intubation (T6～8).The following variables were also recorded:duration of anesthesia and operation,extubation time,regain consciousness time,coughing when extubating,consumption of propofol and sufentanil,and frequency of using vasoactive drugs.Results The occurrence of coughing when extubating was decreased (5 vs 14,P＜0.05),and the requirements of propofol,sufentanil,urapidil and esmolol were decreased [(385±120) mg vs (493±158) mg,P＜0.05; (33±7)μg vs (38±6) μg,P＜0.01; 4 vs 12,P＜0.05; 4 vs 11,P＜0.05)],but the requirement of atropine was increased in group D than in group C(6 vs 2,P＜0.05).Compared with To or every time points of group D,MAP was significantly decreased at T3-8 in group C (P＜0.05).MAP was significantly high in group D at T1 (P＜0.05).HR was significantly low in group C at T4 and T5 (P＜0.05).In addition,HR decreased in group D at T1-8(P＜0.05 ),and HR was lower in group D than in group C at T1-3 and T6-8(P＜0.05 ).Conclusion 0.6 μg/ kg Dex given intravenously before induction is beneficial to general anesthesia patients undergoing laparoscopic cholecystectomy. Key words: Dexmedetomidine; Laparoscopic cholecystectomy; General anesthesia