Therapeutic effects of hyperbaric oxygen,anisodaminum and dexamethasome on blast injury in rats exposed to high altitude

Objective To investigate the treatment effect of hyperbaric oxygen,anisodaminum and dexamethasone on blast injury at high altitude.Methods Rats at waking state were exposed to 3500m above sea level for 6 hours at an experimental device of high altitude blast injury.Then rats were inflicated with blast injury by a BST-Ⅰ shock tube at the peak pressure of(343.5±4.176)kPa.They were divided into four groups: group A(control group) without receiving any treatment;groups B,C and D(treatment groups) were given hyperbaric oxygen,anisodaminum(1mg/kg) and dexamethasone(1mg/kg),and combined application of hyperbaric oxygen plus anisodaminum and dexamethasone at 0.5 hours and 3 hours after injury,respectively.Mortality rate,blood gas and pulmonary morphological changes were observed at 6 hours after injury.Results The mortality rates were 40.7%,17.4%,24.0% and 14.3% in groups A,B,C,D,respectively.A significant difference in the mortality rate was observed between group A and D(P0.05).The levels of PaO2 were(65.250±11.311),(82.286±5.908),(72.625±11.783) and(85.125±7.322)mmHg,respectively.There was significant difference in groups B and D as compared with group A(P0.01).The levels of SaO2 were(90.5±4.840)%,(95.429±1.339)%,(93.625±2.925)% and(95.750±0.661)%,respectively.There was significant difference in group B(P0.01),C(P0.05) and D(P0.01) as compared with group A.Pulmonary hemorrhage and edema were relieved in groups B and D as compared with group A,but they were exacerbated in groups C as compared with group A.Conclusion Hyperbaric oxygen,anisodaminum and dexamethasone,as well as combined application of hyperbaric oxygen,anisodaminum and decamethasone are effective to treat blast injury exposed to high altitude in rats.Moreover,the combined application of hyperbaric oxygen,anisodaminum and decamethasone is more effective.