Paraneoplastic limbic encephalitis with double positive anti-Hu and Yo antibodies: a case report

Paraneoplastic neurological syndromes (PNS) are a rare group of immune-mediated disorders that affect the central and peripheral neuromuscular system in association with cancer. If the limbal lobe system of the brain is involved, it will show paraneoplastic limbal encephalitis (PLE).The discern of patients with PNS is challenging since tumors causing paraneoplastic neurologic disorders are often asymptomatic and sometimes occult. We report a case of PLE with double positive anti-Hu and Yo antibodies, and further analyze and discuss it in conmbination with relevant literature to improve the understanding of the disease. Key words: Paraneoplastic syndromes, nervous system; Limbic encephalitis; Autoantibodies