Effect of Non-Surgical Periodontal Therapy on C-Telopeptide Pyridinoline Cross-Links (ICTP) and Interleukin-1 Levels

Background: Biochemical markers harvested from gingival crevicular fluid (GCF) may be useful to identify and predict periodontal disease progression and to monitor the response to treatment. Ctelopeptide pyridinoline cross-links (ICTP), a host-derived breakdown product specific for bone, and interleukin-1β (IL-1), a potent boneresorptive cytokine, have been associated with periodontal tissue destruction. The aim of this study was to examine the effect of nonsurgical periodontal therapy on GCF levels of ICTP and IL-1. Methods: Twenty-five chronic periodontitis subjects were monitored at 8 sites per subject at baseline prior to scaling and root planing and 1, 3, and 6 months after therapy. Four shallow (probing depths <4 mm) and 4 deep (probing depths ≥5 mm) sites were monitored for both marker levels and clinical parameters. GCF was collected for 30 seconds on paper strips, and levels of ICTP and IL-1 were determined using radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) techniques, res...