MANDIBULAR BROWN TUMOR AS ATYPICAL PRESENTATION OF PRIMARY HYPERPARATHYROIDISM: TWO CASE REPORTS AND LITERATURE REVIEW

Objective. We report two cases of patients who developed solitary expansive mandibular tumor of aggressive behavior who were surgically removed in suspicion of malignancy with histopathological diagnosis of Central Giant Cell Granuloma and Giant Cell Bone Tumor in patients undiagnosed of primary hyperparathyroidism (PHTP). Methods: Two cases report and review of the literature. Results: We present two cases of single mandibular tumor with aggressive, expansive, rapidly evolving behavior. In both cases, a malignant tumor process was suspected and the lesion was surgically resected. The histopathological diagnosis was Giant Cell Bone Tumor (GCTB) in one and Central Giant Cell Granuloma (CGCG) in the other. We are unaware of their biochemical studies of both patients at the time of the intervention. Several months later, they were sent to the Endocrinology Service for hypercalcemia. One of them presented hypercalcemic crisis and pancreatitis and the other a pathological fracture of humerus. The diagnosis of ...