Association of paired box 9 (PAX9) (rs12881240) and muscle segment homeobox 1(MSX1) (rs12532) gene polymorphisms in human tooth agenesis

Agenesis of one or more teeth is the most common anomaly observed in human craniofacial development. The aim is to test the association between PAX9 (rs12881240) and MSX1 (rs12532) polymorphisms and tooth agenesis in local population. DNA samples of 25 subjects with non-syndromic tooth agenesis and 25 unrelated controls, collected from the department were used for the study. The extracted DNA samples were subjected to Polymerase chain reaction and then subjected to DNA sequencing. This study also suggests that the likelihood of Non syndromic tooth agenesis is higher in subjects having CT (p=0.02) genotype of PAX 9 gene variant rs12881240 & AG (p=0.02) genotype for MSX 1 gene variant rs12532. Conclusion is the PAX 9 gene variant rs12881240 and MSX 1 gene variant rs12532 can be considered as genetic markers for Non-syndromic Tooth agenesis in local population.