Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: An ex vivo experiment in human serous ovarian carcinoma.

Stephanie Lheureux,Monique N'Diaye,Cécile Blanc-Fournier,Audrey-Emmanuelle Dugué,Bénédicte Clarisse,Soizic Dutoit,Florence Giffard,Edwige Abeilard,Mélanie Briand,Alexandre Labiche,Jean-Michel Grellard,H. Crouet,Sandrine Martin,Florence Joly,Laurent Poulain

Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: An ex vivo experiment in human serous ovarian carcinoma.

2014

Stephanie Lheureux
Monique N'Diaye
Cécile Blanc-Fournier
Audrey-Emmanuelle Dugué
Bénédicte Clarisse
Soizic Dutoit
Florence Giffard
Edwige Abeilard
Mélanie Briand
Alexandre Labiche
Jean-Michel Grellard
H. Crouet
Sandrine Martin
Florence Joly
Laurent Poulain

5577 Background: Ovarian cancers are addicted to Bcl-xL and Mcl-1, anti-apoptotic members of the Bcl-2 family. Bcl-xL can be inhibited by the BH3-mimetic ABT-737. In vitro, ABT-737 can induce apopt...

Keywords:

Carcinoma
Pathology
Ex vivo
Serous fluid
Cancer research
Medicine
ovarian carcinoma
In vitro
bh3 mimetic

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