Models of Hematopoietic Dynamics Following Burn for Use in Combined Injury Simulations

Abstract : The effects of thermal injury were incorporated into previously developed models that simulate hematopoiesis in humans following acute radiation exposure. These include models of thrombopoiesis, granulopoiesis, and lymphopoiesis. In thrombopoiesis, burn leads to platelet consumption and an increase in circulating stimulatory mediators. In granulopoiesis, burn leads to an increased bone marrow release rate, granulocyte demargination, granulocyte uptake into the tissue, and an increased mitotic progenitor repopulation rate. In lymphopoiesis, burn increases the rate of lymphocyte clearance. The models were validated against human data from subjects with different burn sizes. Model outputs were compared to combined injury data from animals to verify that trends were accurately predicted. Outputs from these models will be correlated with mortality, and this information will assist in disaster preparedness and medical resource planning.