Study on effect of tiotropium bromide powder inhalation in treatment of stable Moderate to severe chronic obstructive pulmonary disease

Objective To explore the effect of tiotropium bromide powder inhalation in treatment of stable moderate to severe chronic obstructive pulmonary disease (COPD).Methods 90 cases of stable moderate to severe COPD admitted into our hospital from February 2010 to March 2012 were selected as objects.They were randomly divided into control group and experiment group,45 cases for each group.Routine nursing was given to two groups and tiotropium bromide powder inhalation was given to the experiment group.The pulmonary function indicatrix before taking medicine,6 and 12 weeks after taking medicine of them was recorded,including FEV1,FVC,IC,6MWD and adverse effects rate.Results After 6 and 12 weeks treatment,the FEV1,FVC,IC and 6MWD in the experiment group were superior than those of control group,the difference was statistically significant (P ＜ 0.05).The adverse effects rate was 8.9％ in the control group and 4.4％ in experiment group,thc difference was statistically significant (P ＜ 0.05).Conclusions We think that tiotropium bromide powder inhalation has great effect on stable moderate to severe COPD.It is safe and worth to be widely promoted in clinic. Key words: Tiotropium bromide powder inhalation; Stable moderate to severe chronic obstructive pulmonary disease; Treatment effect