Effects of Immature Coconut Water on the Hepato- Cytoarchitecture Against Carbontetrachloride-induced Liver Damagein Wistar Rats

The peculiar features of immature coconut water (ICW) have made it a therapeutic agent that can be used extensively in the field of medicine for both preventive, management and curative purposes. Development of a more efficient and cost effective means of prevention and management of liver disorders through antioxidant activities were the objectives for embarking on the current experiment. This experiment is aimed at investigating the protective effect of ICW against carbon tetrachloride (CCl4) induced hepatotoxicity. 20 rats were fed on standard diet and divided into four groups. Rats in group 1 and group 2 were injected intraperitoneally (i.p) with olive oil. Group 1 received tap water only, while group 2 received ICW (100ml/kg body weight/day) only. Rats in Group 3 and Group 4 were injected i.p with CCl4 (5ml/kg body weight). Group 3 received tap water, while group 4 received ICW (100ml/kg body weight/day) only. At the end of the experiment (1 week), liver samples were collected for histopathological analysis. The present findings revealed that a significant cyto-architectural distortion, hepatocyte degeneration, necrotic cells, fatty liver, and inflammatory cell migration were observed in the liver of CCl4 treated group when compared with the normal control, positive control, and the experimental groups. The present study concluded that ICW administration played a protective role against CCl4-induced liver damages in Wister rats. These protective effects were in the form of retaining the histological features of liver in the experimental group.