Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia.

Regina M. Myers,Yimei Li,Allison Barz Leahy,David M. Barrett,David T. Teachey,Colleen Callahan,Christina Fasano,Susan R. Rheingold,Amanda M. Dinofia,Lisa Wray,Richard Aplenc,Diane Baniewicz,Hongyan Liu,Pamela A Shaw,Edward Pequignot,Kelly D. Getz,Jennifer Brogdon,Andrew D. Fesnak,Don L. Siegel,Megan M. Davis,Chelsie Bartoszek,Simon F. Lacey,Elizabeth O. Hexner,Anne Chew,Gerald Wertheim,Bruce L. Levine,Carl H. June,Stephan A. Grupp,Shannon L. Maude

Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia.

2021

PURPOSECD19-targeted chimeric antigen receptor (CAR)–modified T cells demonstrate unprecedented responses in B-cell acute lymphoblastic leukemia (B-ALL); however, relapse remains a substantial chal...

Keywords:

Refractory
CD19
Young adult
Medicine
Immunology
Lymphoblastic Leukemia
car t cells
Chimeric antigen receptor

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