Progress in the reprogramming of induced pluripotent stem cells with small molecules

Induced pluripotent stem cells can differentiate into a variety of cell types, which promote the development of human disease model, drug toxicity screening and sources of autologous cells.However, there have been many problems in the induced pluripotent stem cells reprogramming, such as safety and low efficiency.Small molecules are considered as a promising method to improve the reprogramming processes of induced pluripotent stem cell, and more and more small molecules have been identified to maintain stem cell self-renewal, providing a new approach to produce the desired reprogramming cells. Key words: Induced pluripotent stem cell; Small molecule; Reprogramming