Application of pulse indicator continuous cardiac output during and after lung transplantation

Objective To evaluate the value of pulse indicator continuous cardiac output (PiCCO) measurement during and after lung transplantation. Methods Eleven cases of ASA class Ⅲ or Ⅳ aged from 34 to 68 years undergoing lung transplantation were enrolled in this randomized,double-blind trial (7 cases of idiopathic pulmonary fibrosis patients, 3 cases of COPD and 1 case of silicosis patent), the CVP, Swan-Ganz, and PiCCO catheter were inserted in all patients via subclavical vein, internal jugular vein and left femoral artery respectively. The paramcters such as haemodynamics and PiCCO data of all patients were recorded at T0, T1, T2, T3, T4, T5 and T6 (T0, T1, T2, T3, T4, T5 and T6 were represented the time of the beginning of double-lunged and single-lunged ventilation, lung artery clipping and opening, operation completing and 8 or 24 h after operation respectively). At the end of this clinical trial, all measurement data were expressed as mean ± standard deviation, and correlation analysis was used for PiCCO versus CCO, ELWI versus PVPI and SVI versus GEDI, ITBI, CVP and PAWP, disposed by SPSS 13.0 software. Results PAP value at T1 and T2 grew larger than at T0 (P 0. 05). Related coefficients of ELWI and PVPI, and PiCCO and CCO were 0.82 and 0.84 respectively (P<0.01 ). Conclusion PiCCO monitoring can reflect the change of pulmonary vascular permeability precisely, which maybe provide timely and considerable evidence and proof for clinicians to diagnose and treat during and after lung transplantation. Key words: Cardiac output;  Lung transplantation;  Preload;  Permeability, blood vessel