Abstract 13810: TT-00920, a Clinical Stage Novel Phosphodiesterase 9 Inhibitor, Protects Against Heart Failure in a Rat Model of Myocardial Infarction

Sheng Zejuan,Xiaoyan Qiang,Guoyu Li,Huimin Wang,Wenxin Dong,Frank Wu

Abstract 13810: TT-00920, a Clinical Stage Novel Phosphodiesterase 9 Inhibitor, Protects Against Heart Failure in a Rat Model of Myocardial Infarction

2020

Sheng Zejuan
Xiaoyan Qiang
Guoyu Li
Huimin Wang
Wenxin Dong
Frank Wu

Introduction: Phosphodiesterase 9 (PDE9) controls natriuretic-peptide-stimulated cyclic guanosine monophosphate in cardiac myocytes and is stongly upregulated in human heart failure, suggesting its...

Keywords:

rat model
Myocyte
Heart failure
Downregulation and upregulation
Myocardial infarction
human heart
Cyclic guanosine monophosphate
Pharmacology
Medicine
Phosphodiesterase

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