E-217 Voxel based calculation of aneurysm volume and morphological characteristics

Introduction Various embolization techniques are available for intracranial aneurysms. The volume of an aneurysm is of interest for the device selection and delivery of a variety of embolization techniques, such as: coils, liquid embolics, flow disruptors, and flow diverters. Accurate aneurysm sizing and volumetric information can help interventionalists assess flow and stability pre-treatment, and assess potential remnant or recanalization risks post-treatment. Materials and Methods This research project applies voxel-based volume calculations, from patient MRI medical imaging data, to determine accurate 3-D aneurysm volume calculations. Additionally, the application can display clinically relevant parameters, such as aneurysm neck diameter, dome height and midline-dome width (for dome: neck (D:N) ratio calculations. To develop the calculations, formalin-fixed canine aneurysms model samples are measured with a Bruker 7T® MRI and reconstructed in 3-D. (figure 1). The images is be processed using a MATLAB® algorithm. This algorithm patches together image segments from MRI and micro CT scans of animals and/or humans. The application acquires 3D MRI data, discretizes the domain intrasaccular aneurysm space, and evaluates the volume of the aneurysm sac. This data is compared to physical measurements of excised aneurysms and calibrated 2-D angiographic images. Results Imaging processing techniques may be used to determine the domain of aneurysms with unprecedented precision, with less than 5% volumetric error, whereas current measurement techniques, especially in 2-D planes have errors as high as 30%. This technique helps determine the macroscopic properties of aneurysms, as well as accurately calculate the volumes of heterogeneous features such as blebs or abnormal aneurysm shapes. Conclusion This project brings together clinical and engineering expertise to translate medical imaging data directly into volumetric measurements with highly precise calculations that are currently not available from 2-D angiographic images. Measuring the size and dimensional properties of aneurysms with voxel-based volume calculations provides a fast, reliable and repeatable resource for aneurysm assessment. This technique will help interventionalists appropriately asses risk and treatment options for a broad variety of aneurysm morphologies. Disclosures C. Settanni: None. T. Becker: 1; C; STTR (NIH). 2; C; Aneuvas. W. Merrit: 1; C; STTR(NIH). 2; C; Aneuvas.