Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias

AbstractPyrethroid insecticides are widely used for pest control in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging se