The effect of Megestrol combined with diethylstilbestrol on the quality of life in patients with advanced prostate carcinoma

Objectives To investigate the effect of Megestrol combined with diethylstilbestrol on inpatients with advanced prostate carcinoma.Methods Sixty-five cases of advanced prostate carcinoma with bone metastasis were randomly divided into two groups,33 cases of the controlled group(A) were treated with routine therapy alone,35 cases of the therapeutic group (B) were treated with plus Megestrol and diethylstilbestrol.The changes of weight,pain,KPS and PSA were observed in each group.Results Cases in the B group showed improvement of pain,increasement of weight and Karmofsky score,especially for PSA showed to drop off obviously.The differences in two groups were significant(P ＜0.01).There was no obvious toxicity.Conclusions The treatment of Megestrol combined with diethylstilbestrol has beneficial effects on the quality of life in patients with advanced prostate carcinoma and can drop off the level of PSA,its side effect is not significant. Key words: Prostatic Neoplasms; Megestrol; Hexestrol