Effect of lung and kidney injury sequence on prognosis in patients with paraquat poisoning

Objective To investigate the effect of lung and kidney injury sequence on prognosis in patients with paraquat poisoning. Methods A total of 175 cases of paraquat poisoning admitted to the emergency department of the First Affiliated Hospital of Nanchang University from October 2010 to August 2018 were analyzed retrospectively, including 60 males and 115 females, aged 14-79 years, with an average age of (36.55±16.13)years. The 175 cases of paraquat poisoning were divided into 3 groups according to the sequence of lung and kidney injury. Renal injury was prior to lung injury group(Group A, 68 cases), lung injury was prior to kidney injury group (Group B, 42 cases), and lung and kidney damage group (group C, 65 cases). The data between each group were recorded, including dose of poisoning, the time from poisoning to gastric lavage, the time from poisoning to admission, age, gender, the time from poisoning to lung damage, and the time from poisoning to kidney damage, to compare the prognosis of patients with improvement or death. Results There was no statistically significant difference between the three groups in terms of the time from taking poison to gastric lavage, the time from taking poison to admission, and gender (P>0.05). There were statistically significant differences in the dose and age (P 0.05), while there was a correlation of dose on prognosis (P<0.001). The prognosis of group A was better than that of group B, and the difference is statistically significant (χ2=8.32, P<0.01); the prognosis of group B was better than that of group C, and the difference was statistically significant (χ2=21.04, P< 0.001). Conclusion The order of lung and kidney injury sequence has an impact on the prognosis: patients with simultaneous lung and kidney damage have the worst prognosis; the prognosis of the patient with kidney damage prior to lung damage is better than that of the patient with lung damage prior to kidney damage. The dose of poisoning also has good value for the prognosis. Key words: Prognosis; lung injury; kidney injury; paraquat poisoning