Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk

// Jie Gao 1, * , Xinghan Liu 2, * , Linting Wei 1, * , Dan Niu 3 , Jiali Wei 4 , Li Wang 1 , Heng Ge 1 , Meng Wang 2 , Qiaoling Yu 5 , Tianbo Jin 6 , Tian Tian 2 , Zhijun Dai 2 , Rongguo Fu 1 1 Department of Nephrology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China 2 Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China 3 Department of Nephrology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China 4 Department of Nephrology, Hainan general hospital, Haikou 570311, China 5 Department of Pathology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China 6 National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi’an 710069, China * These authors have contributed equally to this work Correspondence to: Jie Gao, email: gxej_cn@sina.com Rongguo Fu, email: pipifu@126.com Keywords: monocyte chemoattractant protein-1, IgA nephropathy, polymorphism, risk, case-control study Received: September 16, 2016     Accepted: October 12, 2016     Published: October 24, 2016 ABSTRACT Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 stimulate inflammation response by activating and recruiting monocytes/macrophages. MCP-1 and CCR2 polymorphisms were reported to be associated with various diseases. To explore the relationship between MCP-1 and CCR2 polymorphisms and IgA nephropathy (IgAN), we conducted this case-control study by enrolling 351 IgAN patients and 310 health controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate potential associations of MCP-1 and CCR2 polymorphisms with susceptibility and clinical parameters of IgAN. No statistical differences between IgAN group and the control group in the MCP-1 -2518 and CCR2 +190 genotypic groups were observed ( P > 0.05). Individuals with MCP-1 -2518 GG genotypes had a higher blood pressure (GG vs. AA+AG: OR = 1.79, 95% CI = 1.07-2.99, P = 0.026) and Lee’s grade (GG vs. AA+AG: OR = 2.05, 95% CI = 1.19-3.54, P = 0.009; GG vs. AA: OR = 2.24, 95% CI = 1.19-4.20, P = 0.01), compared with patients with AA/AG genotypes. A significant association between CCR2 +190 polymorphism and Lee’s grades was observed (GA+AA vs. GG: OR = 2.66, 95% CI = 1.63-4.35, P < 0.001; GA vs. AA+GG: OR = 2.27, 95% CI = 1.39-3.70, P = 0.001). Our results indicated that MCP-1 and CCR2 polymorphisms may influence the progression of IgAN, but not increase/decrease its susceptibility.