Preliminary study of levels of coagulation factors in cord blood of neonate

Objective To study the levels of coagulation factors in cord blood from normal newborns. Methods The study was clinical experimental study.One hundred and thirty-six cord blood samples collected from newborns who were born in Guangzhou Women and Children′s Medical Center from November 2011 to January 2012.The levels of eight coagulation factors FⅡ,FⅤ,FVⅡ,FVⅢ,FⅨ,FⅩ,FⅪand FⅫin cord blood were detected using CA-1500 Automatic Blood Coagulation Analyzer. Results The levels of eight coagulation factors in cord blood: the 95% reference ranges were 27.04%-49.02%,53.30%-116.40%,27.80%-56.70%, 19.16%-113.06%,19.85%-35.65%,24.20%-48.00%,24.40%-42.20% and 9.20%-54.60% respectively.The 99% reference ranges were 23.56%-52.50%,53.30%-116.40%, 27.80%-56.70%,4.31%-127.91%, 17.35%-38.15%,24.20%-48.00%,24.40%-42.20% and 9.20%-54.60% respectively. Conclusion The study establishes the reference ranges for levels of coagulation factors in cord blood,it will provide experimental basis for diagnosis and differential diagnosis for neonatal congenital or hereditary coagulation factor deficiency.(Chin J Lab Med,2013,36:850-853) Key words: Fetal blood; Blood coagulation factors; Infant; newborn