ANTIOXIDANT SYSTEMS IN NORMAL AND PREECLAMPTIC ALGERIAN PREGNANT WOMEN

Preeclampsia affects 5 to 7% of all pregnancies and is one of the most common, yet least understood, disorder of pregnancy. It is also a leading cause of maternal and perinatal mortality worldwide. Damage from free radicals has been implicated in preeclampsia. This study was undertaken to investigate the relationship between the oxidative stress linked to preeclampsia and the possible antioxidant status modifications. We measured plasma thiobarbituric acid reactant (TBARs), Zn, Se, Vit A, E, and Beta-Carotenes and CuZnSOD, SeGPx erythrocytes, in 2 groups of pregnant Algerian women [40 preeclamptic = 27 moderate and 17 severe preeclampsia] compared to 40 normal pregnant women, We observed an increased in plasma TBARs which was significantly higher in women with preeclampsia [3.51 ± 0.45 vs 2.97. ± 0.38 μmol/l], but there were no significant differences into the preeclamptic group [3.55 ± 0.49 vs 3.42 ± 0.37μmol/l]. When adjusting to cholesterol, the peroxidation remained significantly increased [TBARs/Cholesterol ratio: 1.41 t 0.35 vs 1,18 t 0.26pmoi/I]. The plasma cholesterol was unchanged in the two groups [2.59 t 0.52 vs 2.59 ± 0.43 g/I]. Plasma triglycerides were higher in women with preeclampsia (3.33 t 1.00 vs 2.70 t 0.84gl1], especially in the severe prec1omposia [3.14 ± 1,06 vs 3,71± 0.793 We observed no difference in status concerning antioxidant [Zn, Se, Vit A, E. and Beta-Carotones] or in enzymatic antioxidants (CuZnSOD, SeGPX).