Motor function impairment in chronic HIV is similar but less severe to that seen in Parkinson’s disease (P6.080)

Objective: To determine if motor function deficits in people aging with human immunodeficiency virus (HIV) infection resemble those observed in people with Parkinson’s disease (PD). Background: Advances in anti-retroviral therapy (ART) have allowed people diagnosed with HIV to live longer but potentially develop HIV-associated neurocognitive disorder and functional brain network degradation. Brain networks affected by HIV are similar to those affected in PD, but whether this results in similar motor control disorder is less clear. Design/Methods: PD subjects in the off-therapy state (N = 23), HIV subjects (N = 21) and healthy aging control subjects (N = 19) performed quantitative fine motor control and gait tasks: rapid alternative finger tapping (RAFT) on an engineered keyboard, validated with the Unified Parkinson’s Disease Rating Scale (UPDRS III), and repetitive stepping in place (SIP), validated with the PD Freezing of Gait Questionnaire. We have shown that arrhythmicity is the RAFT measure most sensitive to the UPDRS III and gait arrhythmicity is a marker of freezing of gait (FOG). Movement was also rated with the UPDRS III. Results: During RAFT, HIV and PD groups were both more arrhythmic (P Conclusions: Validated quantitative kinematics revealed chronic HIV infection resulted in similar, but less severe, motor function impairment as PD. The UPDRS III was not sensitive to disease abnormalities. These results provide insight into the progression of HIV-associated motor decline. Disclosure: Dr. Bronte-Stewart has nothing to disclose. Dr. Prabhakar has nothing to disclose. Dr. Martin has nothing to disclose. Dr. Trager has nothing to disclose. Dr. Velisar has nothing to disclose. Dr. Koop has nothing to disclose. Dr. Muller-Oehring has nothing to disclose. Dr. Poston has nothing to disclose. Dr. Schulte has nothing to disclose.