IN SITU DUKTÁLIS EMLŐKARCINÓMA KOMBINÁLT SEBÉSZI- ÉS SUGÁRKEZELÉSE: A MAGYARORSZÁGI MULTICENTRIKUS PROSPEKTÍV RANDOMIZÁLT VIZSGÁLAT

tient groups. In the high-risk group, 4 (1.7%) local recurrences and 1 (0.4%) distant metastasis occurred. No patient died of breast cancer. In the high-risk group of patients, the 3- and 5-year probability of local recurrence was 1.1% and 3.1%, respectively. The positive immunostaining for Her2 (38%), p53 (37%) and Ki-67 (44%) correlated with a high nuclear grade. Signifi cant inverse correlation was found between the expression of ER (77%), PR (67%), Bcl-2 (64%) and grade. Preliminary results suggest that breast-conserving surgery followed by radiotherapy yields an annual local recurrence rate of less than 1% in patients with DCIS. IHC of molecular prognostic markers can assist to gain insight into the biologic heterogeneity of DCIS. Polgar C, Orosz Z, Kahan Z, Gabor G, Jani N, Cserni G, Hadij ev J, Kulka J, Sulyok Z, Boross G, Lazar G, Laszlo Z, Diczhazi C, Udvarhelyi N, Szabo E, Pentek Z, Major T, Fodor J. Combined surgery and radiotherapy in the treatment of ductal carcinoma in situ of the breast: Preliminary results of the Hungarian multicentric prospective randomised study. Hungarian Oncology 52: 269–277, 2008