The Pathophysiology of Myeloma Bone Disease: Role of Osteoblasts and Osteocytes

Osteolytic bone disease is the hallmark of multiple myeloma (MM). A severe imbalance of the bone remodeling process occurs in close contact with MM cell infiltration that induces an increased osteoclast (OCL) recruitment and activity, together with the suppression of bone formation. The hallmark of osteolytic lesions in MM is the lack of bone healing due to the suppression of the bone formation process.