Interacción entre la aspirina y el ibuprofeno en la hemostasia de ratas Sprague Dawley

espanolEl ibuprofeno es el analgesico antiinflamatorio no esteroideo (AINES) mas utilizado para tratar la inflamacion y el dolor orofacial. Se han reportado interacciones farmacologicas entre el ibuprofeno y otros medicamentos incluyendo el Acido acetil salicilico (aspirina), AINEs prototipo del grupo y ampliamente utilizado como antitrombotico; sin embargo, los resultados de estudios previos son contradictorios. Algunos pacientes odontologicos medicados con aspirina pueden ser tratados simultaneamente con ibuprofeno; por ello, el objetivo de esta investigacion fue establecer si la combinacion de aspirina e ibuprofeno altera la hemostasia en ratas Sprague Dawley con heridas labiales, y si el efecto de la interaccion depende de la secuencia de administracion de los medicamentos. Sesenta ratas machos fueron distribuidas en 6 grupos de 10 cada uno y tratadas una vez al dia, por via intragastrica con aspirina (80 mg/Kg) o ibuprofeno (40 mg/Kg) durante 14 y 7 dias, respectivamente; y con las combinaciones: aspirina seguida del ibuprofeno (aspirina + ibuprofeno) y aspirina despues del ibuprofeno (ibuprofeno + aspirina), dos grupos control recibieron agua destilada. Al finalizar los tratamientos se determinaron los tiempos de sangria, coagulacion y protrombina. Se demostro que los animales tratados con monoterapia y con la combinacion ibuprofeno + aspirina, no presentaron cambios significativos en la hemostasia (p>0,05); mientras que la combinacion aspirina + ibuprofeno aumento significativamente el tiempo de sangria, en comparacion con los grupos: control aspirina (p EnglishIbuprofen is a nonsteroidal anti-inflammatory drug (NSAID) of first election to treat inflammation and orofacial pain. There are works published about pharmacological interactions between ibuprofen and others medicaments, including the Acid acetylsalicylic (aspirin), prototype of NSAID and widely used as antithrombotic. However, the results of previous studies are contradictory. Some dental patients who are medicated with aspirin can be treated simultaneously with ibuprofen, for this reason, the aim of this research was establish if the combination between aspirin and ibuprofen affects the hemostasis in Sprague Dawley rats with labial wounds, and if the effect of interaction depends on the medicaments administration sequence. Sixty male rats were distributed in 6 groups, of 10 each one, and treated once a day by via intragastric with aspirin (80 mg/Kg) or ibuprofen (40 mg/Kg) for 14 or 7 days, respectively; aspirin and later ibuprofen (aspirin - ibuprofen), and ibuprofen and later aspirin (ibuprofen - aspirin). Two control groups received distillated water. At the end of treatments the times of bleeding, coagulation and prothrombine were recorded. It was demonstrated that the animals treated with monotherapy and with ibuprofen followed by aspirin, did not present significant changes in hemostasis (p>0,05); while the combination aspirin plus ibuprofen significantly increased the time of bleeding, in comparison with the groups: control (p