Electrospun nanobandage for hydrocortisone topical delivery as an antipsoriasis candidate

ABSTRACTThe aim of the present work was to introduce the novel and convenient nanoapproach for more effective control of psoriasis. In this study, the polyacrylonitrile (PAN)-based electrospun fiber-loaded hydrocortisone was prepared with a topical electrospinning process. The results showed that the nanofibers had a smooth surface with an average diameter of 288.62 ± 46.42, 195.96 ± 35.60, and 160.11 ± 30.11 and the tensile stress of 1.74, 3.77, and 15.35 MPa for PAN, PAN with 1 and 5% Tween 80, respectively. The amorphous dispersion of hydrocortisone in the nanobandage was proved by X-ray diffraction and differential scanning calorimetry study. The presence of Tween 80 increased drug released to completely 100% in investigated period with positive effect. The cytotoxicity study proved the noncytotoxicity of fibers against human umbilical vein endothelial cell line.