5-Aryl-dimethylamino quinoline-derived two-photon sensitive probes

2-Hydroxymethylene-8-dimethylamino quinoline-(DMAQ) derived photosensitive probes were prepared and tested under 366 nm and 730 nm 150 fs pulsed (“two-photon”) irradiation conditions. Brief bursts of photolysis of 250 μM solution of the kainate derivative of 2f generated sufficient kainate in a small spot to excite large inward currents and somatic spiking in Purkinje neurons.