Acetone and 6-Methyl-5-Hepten-2-One in Skin Gas Increase during Handgrip Exercise

The present study investigated the effect of dynamic handgrip exercise on acetone, 6-methyl-5-hepten-2-one, acetaldehyde, and hexanal levels in skin gas. Participants in this experiment consisted of six healthy males. Skin gas was collected two times. First, skin gas during rest (i.e., before the exercise) was collected for 3 min into the sampling bag. Next, the exercise using a handgrip exercise instrument was performed. The hand performed a dynamic handgrip exercise for 3 min inside the sampling bag, exerting one 30 kg contraction per second. The blood flow at the end of the handgrip exercise increased by about 1.4 times that before exercise and then decreased to basal levels immediately thereafter. Acetone and 6-methyl-5-hepten-2-one concentrations after exercise significantly increased relative to basal levels. Significant differences were not observed in acetaldehyde and hexanal concentrations between at rest and after handgrip exercise. The amount of acetone and 6-methyl-5-hepten-2-one released from forearm skin increased during dynamic handgrip exercise. Acetaldehyde and hexanal levels did not increase during exercise compared with levels at rest.