Depression and survival of glioma patients: A systematic review and meta-analysis.

2025Background: There is currently a lack of well-established meta-analyses examining the association between depression and patient survival in glioma patients. The aim of this meta-analysis was to study the effect of depression on glioma patients' survival. Methods: A meta-analysis was conducted according to the PRISMA guidelines. PubMed, Embase, and Cochrane databases were searched for studies that reported depression and survival among glioma patients through 11/06/2016. Both random-effects (RE) and fixed-effect (FE) models were used to compare survival outcomes in glioma patients with and without depression. Results: Out of 619 identified articles, six were selected for the meta-analysis. Using RE model, the various measures of survival outcomes displayed worsened outcomes for both high and low grade glioma patients with depression compared to those without depression, with an overall pooled risk ratio for survival of 0.67 (95%CI: 0.46, 0.99; I2 = 51.4%, P-heterogeneity = 0.06); an overall pooled sta...