Preliminary clinical study of myocardial imaging agent ~(99m)Tc-NOET

Objective:To study the myocardial redistribution and clinical evaluation of myocardial imaging agent 99m TcNOET 〔bis(Nethoxy, Nethyl dithiocarbamato) nitrido 99m Tc〕. Method:52 patients with coronary artery disease underwent exercise myocardial perfusion scintigraphy and nuclide myocardial redistribution imaging, the former was undergone at 30 min and the latter was performed at 3 to 4 h after injection of 99m TcNOET.Result:40 of 52 cases showed the relative hypoactivity (the activity was reducted or defected) in one or one more segments of myocardium during exercise myocardial perfusion scintigraphy with 99m TcNOET. Of these abnormal segments, while, 38 of 40 cases showed improved activity on the images obtained 3 to 4 h after 99m TcNOET injection. All of imaging results coincided with the clinical diagnosis. 4 of 5 cases imaging 99m TcNOET were paralled with coronary angiography. Conclusion: The 99m TcNOET has significant character of myocardial redistribution as a myocardial perfusion imaging agent. It can be used to observe and evaluate the myocardial ischemia.