Intrinsically fluorescent hollow spheres based on organic–inorganic hybrid polyphosphazene material: Synthesis and application in drug release

Abstract Highly cross-linked organic–inorganic hybrid porous poly [(cyclotriphosphazene-co-resveratro)] spheres with hollow structure were prepared via precipitation polymerization of hexachlorocyclotriphosphazene and resveratrol. Poly [(cyclotriphosphazene-co-resveratro)] spheres mesoporous hollow spheres with resveratrol structures maintained intrinsical fluorescence and outstanding dispersability in both aqueous and organic media for their abundant functional groups. Besides, these cross-linked polyphosphazene spheres manifested high drug storage capacity and remarkable sustained release property. Moreover, the release rate of the drug from polyphosphazene microspheres was greatly dependent on pH value with resveratrol as a model molecule.