Emerging Opportunities for Targeting the Tumor–Stroma Interactions for Increasing the Efficacy of Chemotherapy

It has become evident that tumor cells utilize survival signals that emanate from the tumor microenvironment to aid in survival and disease progression. Experimental evidence indicates that these same pathways contribute to de novo drug resistance. Identification of the mechanisms underlying the recruitment of accessory cells and survival signals provided by normal cells has provided a novel area for drug discovery for increasing the efficacy of cancer therapy.