The Analysis of Hp′s Pathogenic Factor in the District with a High Incidence of Gastric Carcinoma in Xinin,Qinghai

Objective To analyze the positive rate of the special protein CagA,VacA,UreA and UreB of Helicobacter pylori in the district with a high incidence of gastric carcinoma in Xinin,Qinghai.The relation of the positive rate and diagnosis is also studied.Methods The gastric tissue which was taken through endoscopy was examined by CLO,WS and Western Blot to detect Hp′s infection.The positive rate of Hp′s CagA,VacA,UreA and UreB in patients with Hp infection was examined.Results The positive rate of UreA was significantly lower in chronic superficial gastritis than in duodenal ulcer and compound ulcer,as well as chronic atrophic gastritis,gastric ulcer and gastric cancinoma.However,the positive rate of UreB was notably lower in duodenal ulcer and gastric ulcer than in chronic superficial gastritis,atrophic gastritis.UreB was notably lower in intestinal change,atrophic gastritis and gastric cancinoma than in chronic superficial gastritis and ulcers.UreB increased markedly in chronic superficial gastritis.CagA,VacA were not significantly different between all the diagnosis.Conclusion Hp′s UreA may correlated with serious gastric disease.However,UreB may have protective effect for serious gastric disease.