Expression of Beta1-Integrin and Shh and Their Relationship in Colorectal Cancer

Objective: To investigate the expression of β1-integrin and Shh in colorectal cancer and their relationship.Methods: Immunohistochemical method of SP was used to exam β1-integrin and Shh expression in the cases of colorectal cancer,moreover,the correlation between them were analyzed.Results: In colorectal cancer,positive expression rate of β1-integrin was 59.42%,and the positive expression rate of Shh was 71.01%.Significant differences in the expression of β1-integrin was found in different depth of invasion,lymph node metastasis and TNM staging(all P0.05).No significant differences in the expression of β1-integrin was found in different gender,age and pathological grading,while significant difference in the expression of Shh was only found in different pathological grading(P0.05).A positive correlation was found between the expression of β1-integrin and Shh(P0.05).Conclusion: The positive expression of β1-integrin was related to the depth of invasion,lymph node metastasis and TNM staging,and the expression of Shh and β1-integrin in colorectal cancer was correlated.The combined detection of β1-integrin and Shh may be of important clinical value for evaluating the degree of malignancy of colorectal cancer as well as better understanding the biological basis of cancer and finding effective treatments.