Neurological manifestations in a patient with SLE complicated by TTP

Neurological involvement in Systemic Lupus Erythematosus (SLE) is common, occurring in up to 14 to 75% of patients in different series.1 We describe a case of active SLE complicated by thrombotic thrombocytopenic purpura (TTP) in a 21-year-old woman and discuss the neurological and radiological findings. The significance of early diagnosis of SLE complicated by TTP and its aggressive treatment with plasma exchange and concomitant cyclophosphamide therapy is emphasized.