Evaluation of Tumor Vessel Permeability in Cerebral Neoplasm with Multi-slice Helical CT Perfusion Imaging

Objective To obtain permeability surface (PS) value of cerebral neoplasm by using multi-slice helical CT perfusion imaging, to study tumor vessel permeability of cerebral tumors.Materials and Methods Multi-slice helical CT perfusion imaging was performed in 32 patients with cerebral tumor. The routine plain CT scanning (10mm/i) was to localize the central slice of the tumor. Than the perfusion imaging of the tumor was carried out by using cine scan technique (1 rotastion/0.5s) with slice thickness 5mm/4i, reconstructed slice thickness 10mm/2i, flow rate 3.5ml/s, total dose 50ml, delay time 5s and total scanning time 50s. The scanning images were processed in ADW4.0 workstation. PS values were calculated and PS perfusion images were analyzed.Results The lesions included grade Ⅰ～Ⅱ glioma (n=6), grade Ⅲ～Ⅳ glioma (n=10), metastases (n=8) and meningioma (n=8). PS value was significantly increased in all cerebral tumors. PS value (ml·100g-1·min-1) for grade Ⅰ～Ⅱ, grade Ⅲ～Ⅳ glioma, metastases and meningioma was 5.19～17.543 (9.8442±5.40584), 21.116～49.824 (32.8784±10.70139), 12.294～48.196 (29.6168±14.74735) and 25.253～85.948 (56.2026±17.40347), respectively. Statistically significant difference in PS value existed between each group (P0.01) except for grade Ⅲ～Ⅳ glioma vs. metastases (P05).Conclusion Multi-slice helical CT perfusion imaging is of great value in assessing tumor vessel permeability of cerebral tumors. Significant difference in PS values exists between intra- and extra-cerebral tumors, as well as between benign and malignant intra-cerebral tumors.