Dietary arachidonate in milk replacer triggers dual benefits of PGE 2 signaling in LPS-challenged piglet alveolar macrophages

Background Respiratory infections challenge the swine industry, despite common medicinal practices. The dual signaling nature of PGE2 (supporting both inflammation and resolution) makes it a potent regulator of immune cell function. Therefore, the use of dietary long chain n-6 PUFA to enhance PGE2 effects merits investigation.