Using primary patient data to identify the symptoms of brain metastases to develop a patient-reported outcome measure.

e12515 Background: Increasingly, there has been a public call for direct patient input into the development of patient reported outcome (PRO) measures of treatment benefit in adult oncology clinical trials. Patient involvement is especially important in conditions where there is poor prognosis and comparative treatment benefit is minimal with standard outcome measures such as overall or progression free survival. To develop a PRO instrument specifically for patients with brain metastases (BM), this study interviewed patients in this population and also reviewed the clinical literature to identify the signs and symptoms relevant to BM. Methods: A literature search was performed inMEDLINE for articles published between 2000 and 2010. Individual in-depth interviews were conducted with 19 patients with BM using open-ended questions to elicit the most frequent and the most bothersome symptoms. Patient inclusion criteria included a diagnosis of BM and being eligible for whole brain radiotherapy. Results: The li...