ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huaixiang Hao,Yang Xie,Yue Zhang,Olga Charlat,Emma Oster,Monika Avello,Hong Lei,Craig Mickanin,Dong Liu,Heinz Ruffner,Xiaohong Mao,Qicheng Ma,Raffaella Zamponi,Tewis Bouwmeester,Peter Finan,Marc W. Kirschner,Jeffery A. Porter,Fabrizio C. Serluca,Feng Cong

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

2012

Huaixiang Hao
Yang Xie
Yue Zhang
Olga Charlat
Emma Oster
Monika Avello
Hong Lei
Craig Mickanin
Dong Liu
Heinz Ruffner
Xiaohong Mao
Qicheng Ma
Raffaella Zamponi
Tewis Bouwmeester
Peter Finan
Marc W. Kirschner
Jeffery A. Porter
Fabrizio C. Serluca
Feng Cong

ZNRF3 and RNF43 are identified as negative feedback regulators of Wnt signalling; the stem-cell growth factor R-spondin is shown to potentiate Wnt signalling by inhibiting ZNRF3.

Keywords:

RSPO2
Developmental biology
LRP6
Growth factor
Stem cell
RSPO1
Wnt signaling pathway
Cell biology
LRP5
Biology
Frizzled
Ubiquitin ligase
Receptor

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

598

Citations