Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation

Toru Fujii,Hiroko Segawa,Ai Hanazaki,Shiori Nishiguchi,Sakura Minoshima,Akiko Ohi,Rieko Tominaga,Sumire Sasaki,Kazuya Tanifuji,Megumi Koike,Yuki Arima,Yuji Shiozaki,Ichiro Kaneko,Mikiko Ito,Sawako Tatsumi,Ken-ichi Miyamoto

Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation

2019

Toru Fujii
Hiroko Segawa
Ai Hanazaki
Shiori Nishiguchi
Sakura Minoshima
Akiko Ohi
Rieko Tominaga
Sumire Sasaki
Kazuya Tanifuji
Megumi Koike
Yuki Arima
Yuji Shiozaki
Ichiro Kaneko
Mikiko Ito
Sawako Tatsumi
Ken-ichi Miyamoto

Background Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated.

Keywords:

Endocrinology
Sodium
Phosphorylation
Internal medicine
Parathyroid hormone
Protein kinase C
Pi
Excretion
Transporter
Phosphate
Medicine
Xenopus
Cell biology
apical membrane
Threonine
Kinase
Reabsorption

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