Tyrosine Phosphorylation of Shc Proteins in Normal CD34 + Progenitor Cells and Leukemic Cells

To the Editor: After the Shc gene was identified, biological function studies have focused on the oncogenic potentials of Shc proteins, especially their role in the Ras-dependent mitogen-activated protein kinase activation.[1][1] [2][2] Jucker et al[3][3] reported in Blood that Shc proteins are