P16 staining patterns and their relationships with clinical parameters in cases of cervical intraepithelial neoplasia

The aim of this study is to investigate the contribution of the p16 immunohistochemical marker in the cervical intraepithelial neoplasia (CIN) cases in the distinction between CIN1, CIN2, CIN3 and the relationship of CINs with age, localization. CIN1, CIN2, CIN3 preparations of 2015 in the pathology department were retrospectively analyzed. New sections of 3 �m thickness were obtained on polylysine slides from paraffin blocks of these tissues. Samples with immunohistochemical staining with p16 were evaluated under a light microscope.p16 expression was semiquantitatively assessed according to staining intensity with 4 staining levels as score 0,1,2,3. As a result of the Kruskal-Wallis test, a significant difference was found between the scores in the CIN groups (p