The effect of telithromycin on inflammatory markers in chronic obstructive pulmonary diseases
2009
Aim : To evaluate the anti-inflammatory effect of telithromycin on
sputum interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α),
myeloperoxidase (MPO) levels in patient with chronic obstructive
pulmonary diseases (COPD). Methods : Thirty four patients with mild to
moderate COPD were enrolled in this prospective, single center,
double-blind, placebo controlled study. Subjects received either
telithromycin or placebo for 10 days. Before and after treatment period
spirometric tests, arterial blood gas analyses were performed, sputum
samples were taken for measurement of sputum inflammatory markers, and
spu-tum was induced. Results : There was no statistical difference in
baseline clinical or laboratory parameters between groups. After the
treatment, the induced sputum IL-8, TNF-α, , MPO levels is similar
compared with pretreatment levels. Conclusion : In this study,
anti-inflammatory effects of telithro-mycin in stable COPD patients
were not demonstrated. Further studies are needed to determine the
clinical significance of these findings.
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