Cytogenetic Evaluation of Couples With Spontaneous Abortion, Still Birth and Recurrent Miscarriage in Qazvin: Report and Review

Background: Chromosomal abnormality plays an important role in dierent types of miscarriages. Objectives: The present study was designed to investigation chromosomal anomalies in three groups of couples with recurrent abortion (RA), spontaneous abortion (SA) and still birth (SB). PatientsandMethods: In this retrospective study, the frequency of chromosomal aberrations was investigated among 260 couples with miscarriage, which had referred to the cytogenetic section of a reference laboratory in Buali hospilal, Qazvin, Iran from 2009 to 2014. Metaphase spreads were analyzed using G-banding. Results: In this study, 7.6% of couples had chromosomal aberrations including, balanced reciprocal translocations, robertsonian translocations, inversions and sex chromosome aneuploidy. Frequency of balanced translocations was higher, specifically in cou- ples with SA. Conclusions: In this investigation we showed that chromosomal abnormalities could be one of the important causes of miscar- riages. Cytogenetic evaluation of couples, which experienced dierent types of miscarriage, may prevent unnecessary treatments.