What factors drive the choice of a genetic test? A prospective study of the preferences of women with ovarian cancer.

e13621Background: Although genetic testing is recommended for women with epithelial ovarian cancer (EOC), little is known about patient preferences for the various testing options. Our objective was to measure relative preferences for features of genetic testing in women with EOC referred for genetic counseling. Methods: 100 women with EOC and planned referral for genetic testing were recruited to participate in a survey to elicit their preferences for 5 attributes of single gene vs multigene genetic testing, each presented with 2-4 levels: out-of-pocket cost ($0, $100, $250, $1,000), probability of identifying a deleterious mutation (60%, 80%, 88%) or a variant of uncertain significance (VUS) (5%, 20%, 40%), sample requirements (blood or saliva) and turn-around time (1, 2 or 4 weeks). Subjects viewed an educational video and were then asked to choose between 2 unlabeled testing scenarios, each with variations in the levels displayed, with 13 iterations of this task. We used a mixed logit regression to mo...