The effects of creatine phosphate sodium on heart function and NT-proBNP in older patients combination with ischemic cardiomyopathy and intractable heart failure

Objective To observe the effects of creatine phosphate sodium on heart function and B-type natriuretic peptide in patients combination with ischemic cardiomyopathy and intractable heart failure. Methods 70 cases of coronary heart disease combined with ischemic cardiomyopathy and intractable heart failure were randomly(with the random number table)divided into the control group(n= 33)and the creatine phosphate sodium treatment group(n= 37). The control group treated with conventional therapy(digitalis,diuretics,vasodilator,ACEI,et al)ten days;the treatment group with creatine phosphate sodium treatment on the basis of conventional therapy.The symptom,sign of the heart failure patients of the two groups before and after treatment were observed.NYHA cardiac functional grading were estimated.Echocardiography was used to detect left ventricular end-systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF); amino terminal pro brain natriuretic peptide(NT-proBNP)tested by laboratory of the two groups.Drug treatment for 10 days,the changes of the indicators before and after treatment were observed. Results After treatment,compared with the control group[(50.63±4.67)mm,(61.30±4.58)mm].LVESD,LVEDD of the creatine phosphate sodium treatment[(47.16±4.30)mm,(57.92±4.30)mm]significantly decreased(t= 5.73,4.96,all P<0.01),LVEF[(40.57±4.51)%,(37.63±4.53)%]increased significantly(t= 5.53,P< 0.01).After ten days of treatment levels of NT-proBNP decreased in both two groups[(1 659.±248.18)pg/mL,1 899.3 ±205.45]than before treatment[2 043.46±217.04,(2 105.46±239.09)pg/mL](t= 3.23,3.64,all P< 0.05),and the decrease degree of the creatine phosphate sodium treatment group was more obvious than those of the control group(t= 4.11,P<0.05). Conclusion Creatine phosphate sodium can improve the cardiac function and left ventricular ejection fraction of ischemic cardiomyopathy and intractable heart failurepatients,enhance the clinical symptoms of patients. Key words: Ischemic cardiomyopathy; Heart failure,congestive; Creatine phosphate sodium