ALTERATION OF DYNAMIC THIOL DISULPHIDE HEMOSTATIS IN BOTH MATERNAL CIRCULATION AND UMBILICAL CORD BLOOD AND ITS RELATION TO MODE OF DELIVERY

Objective: To evaluate the dynamic thiol disulphide homestasis in  maternal circulation and umbilical cord blood and its relation to mode of delivery. Methods: The study consisted of 35 women with vaginal delivery (VD) and 30 women with cesarean delivery (CS). Blood samples were collected from women at the onset of labor, in early and late postpartum periods and from umbilical cord. Thiol disulphide levels in VD and CS groups were analyzed. Results: Pre-delivery thiols for CS and VD groups were 383.08 ± 51.81 µmol/L vs. 346.13 ± 51.56 µmol/L (p=0.023); early postpartum thiol levels for CS and VD groups were 272.57± 42.78 µmol/l vs 234.50 ± 26.62 µmol/L (p=0.0010 respectively. Pre-delivery thiol levels (346.13 ± 51.56 µmol/L) were decreased to  324.50 ± 26.62 µmol/L in early postpartum perion in VD group (p= 0.031). The same alterations were observed in CS group (383.08± 51.81µmol/L vs. 272.57 ±42.78µmol/L p=0.001). No significant differences were observed in umbilical cord thiol/disulphide levels between two groups. Conclusion: During active phase of labor, oxidative stress increases. It also increases after CS presumably due to response to the surgical intervention and it turns bact to the baseline levels during the late postpartum period. Mode of delivery does not affect oxidative stress in umbilical cord blood.