Prognostic Value of BCL2 in Women Patients with Invasive Breast Cancer

Background: Breast cancers are heterogeneous, making it essential to recognize several biomarkers for canceroutcome predictions especially in young women where the classical prediction parameters are not suitable. The goalfrom this study is to evaluate the impact of B cell lymphoma 2 (BCL2), P53 and Ki-67 proteins expression on survivalin young women patients with invasive ductal carcinoma. Patients and methods: Samples and clinical data from 238patients were collected between 2003 and 2017. They were selected according to 2 criteria: age ≤40 years old and most ofthem are affected by an Invasive Ductal Carcinoma. We evaluated BCL2, P53 and ki-67 expression by immunochemistrytest, and then we assessed correlations of these biomarkers expression with patient’s clinicopathological characteristicsand survival. Results: Triple negative breast cancer group showed a high frequency among our cohort but we emphasizean almost equitable distribution among all molecular groups. Contrary to other studies which reported that luminal Awas correlated with better prognosis, our analysis demonstrated that luminal A is correlated with the Scarff, Bloomand Richardson (SBR) grading 2 or SBR grading 3. To better investigate the prognosis, we analyze three biomarkersknown by their impact on physiopathology behavior on breast cancer BCL2, ki-67and P53. BCL2 is the more relevantone, it was correlated with molecular subtypes (p=0.0012) and SBR grading (p=0.0016). BCL2 seems to be the goodprognostic biomarker related to survival (p=0.004) with a protective role among patients when endocrine therapyis not provided and Lymph Node (LN) involvement is positive (p=0.021, p=0.000 respectively). Conclusions: Theclassical prognostic parameters based mainly on the molecular classification in breast cancer seem insufficient in thecase of young women. BCL2 protein expression analysis provides a better prognostic value. BCL2 should be clinicallyassociated in current practice when young women specimens are diagnosticated.